广东工业大学学报 ›› 2021, Vol. 38 ›› Issue (02): 73-82.doi: 10.12052/gdutxb.200118

• 综合研究 • 上一篇    下一篇

骨植入聚醚醚酮材料表面改性的研究进展

肖天华1,2, 刘荣涛1, 庞贻宇1, 李达1, 刘佳1, 闵永刚1,2   

  1. 1. 广东工业大学 材料与能源学院, 广东 广州 510006;
    2. 东莞华南设计创新院, 广东 东莞 523808
  • 收稿日期:2020-09-11 出版日期:2021-03-10 发布日期:2021-01-13
  • 通信作者: 刘佳(1978-),女,讲师,主要研究方向为生物芯片和生物组织工程、纳米材料等,E-mail:liujia@gdut.edu.cn;闵永刚(1963-),男,教授,博士生导师,主要研究方向为有机光电功能材料与器件、高性能聚合物、能源环保材料、生物芯片和生物组织工程等,E-mail:ygmin@gdut.edu.cn E-mail:liujia@gdut.edu.cn;ygmin@gdut.edu.cn
  • 作者简介:肖天华(1996-)，男，硕士研究生，主要研究方向为生物组织工程
  • 基金资助:
    广东省“珠江人才计划”创新创业团队项目(2016ZT060412)；广东工业大学百人计划项目(220418095)

Progress on Bone Graft PEEK about Surface Modification

Xiao Tian-hua1,2, Liu Rong-tao1, Pang Yin-yu1, Li Da1, Liu Jia1, Min Yong-gang1,2   

  1. 1. School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China;
    2. Dongguan South China Design and Innovation Institute, Dongguan 523808, China
  • Received:2020-09-11 Online:2021-03-10 Published:2021-01-13

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摘要： 聚醚醚酮(Polyetheretherketone, PEEK)是一种半结晶的合成聚合物, 与传统修复骨缺损的生物材料相比, PEEK具有良好的生物相容性、化学稳定性、透光性和弹性模量与正常人骨相似等优点, 已被广泛应用于骨科移植。但PEEK的生物惰性使其在临床应用中存在局限性, 目前通过表面改性赋予PEEK材料表面生物活性是解决这个问题的有效途径。本文综述了近年来PEEK表面改性方法的研究现状和发展方向, 其中着重介绍了物理改性、化学改性以及涂层改性, 并分析了不同改性技术对于提高生物相容性的作用, 最后指出PEEK表面改性骨移植材料在医学领域中继续发展需要解决的问题, 要充分研究其在体内的每一阶段身体所做出的反应, 并保证其表面处理在整个生命周期内不会退化或磨损正常组织。

关键词: 聚醚醚酮, 表面改性, 生物活性, 骨整合, 抗菌

Abstract: Polyetheretherketone (PEEK) is a class of semi-crystalline polymer. Compared with traditional bone repair materials, PEEK possesses good biocompatibility, chemical stability, light transmittance and elastic modulus which is similar to that of normal human bone. Therefore it has been widely used in transplantation. However, the biological inertia of PEEK limits its clinical application. At now, the surface modification is an effective way to solve this problem. The current status of research and direction of development about PEEK surface modification methods in recent years are reviewed. And physical modification, chemical modification and coating modification are emphasized. The effects of different modification technologies on improving biocompatibility were analyzed. Finally, the problems are pointed out that need to be solved for PEEK surface modified bone graft material to continue to develop in the medical field. The body's reaction must be studied fully at every stage after the bone graft material was implanted in the body. And it is ensured that the surface treatment does not degrade or wear away normal tissues throughout the whole life cycle.

Key words: polyetheretherketone, surface modification, bioactivity, bone integration, antibacterial

中图分类号: 

  • R318.08
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