摘要: 为了寻找高效抑菌活性的新型药物,考察了13种含哌嗪基的喹啉衍生物对大肠杆菌、枯草杆菌、金黄色葡萄球菌的体外抗菌活性.结果表明:化合物3i、3j对大肠杆菌、枯草杆菌、金黄色葡萄球菌均有良好的抗菌效果,最低抑菌质量浓度为0.07 mg/mL.
[1]Aik H R P,Naik H S B,Naik T R R,et a1.Synthesis of novel benzo[h]quinolines:Wound healing,antibacterial,DNA binding and in vitro antioxidant activity[J].Eur J Med Chem,2009,44(3):981-989.[2]Via L D,Gia O,Gasparotto V,et a1.Discovery of a new anilino-3H-pyrrolo[3,2-f]quinoline derivative aspotential anti-cancer agent[J].Eur J Med Chem,2008,43(2):429-434.[3]Prescott T A K,Sadler I H,Kiapranis R.Lunacridine from Lunasia amara is a DNA intercalating topoisomerase II inhibitor[J].Journal of Ethnopharmaeology,2007,109(2),289-294.[4]郑贤育,陈昌,高芳华,抗疟新药咯萘啶及其类似物的合成[J].药学学报,1982,2:118.[5]单成启,高徐生.磷酸萘酚喹对人恶性疟原虫体外药效测定[J].军事医学科学院院刊,1995,19(4):317.[6]Kwiek J J,Haystead T A J,Rudolph J.Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines[J].Biochemistry,2004,43(15):4538-4547.[7]周宝石,曾志正.辛可芬与8一羟基喹啉稀土三元配合物的合成及有关烧伤的药学性质研究[J].兰州大学学报:自然科学版,2005,41(3):60-62.[8]王小京.美科学家告诫慎防淋病死灰复燃[J].国外医学情报,2003,24(7):32-33.[9]赖以飞.综合最近开发杀菌剂的作用方式[J].农药译丛,1997,19(1):14-19.[10]吴利欢,杨定乔.2-(取代哌嗪-1-甲基).3-喹啉甲酸.乙酯及其衍生物的合成、表征及晶体结构[J].有机化学,2009,29(7):1122-1128. |
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