PEGDA／NIPAM 共聚物水凝胶的溶胀性能及体积相变研究

广东工业大学学报 ›› 2010, Vol. 27 ›› Issue (3): 5-8.

PEGDA／NIPAM 共聚物水凝胶的溶胀性能及体积相变研究

1．广东工业大学轻工化工学院，广东广州510006；2．华南理工大学材料科学与工程学院，广东广州510641

出版日期:2010-09-25 发布日期:2010-09-25
作者简介:谭帼馨(1971-)，女，副教授，博士，主要研究方向为生物医学功能材料
基金资助:
国家自然科学基金资助项目(50502015，50872035)；广东省自然科学基金资助项目(06300082)

A Study of Swelling Properties and Volume Phase Transition of PEGDA／NIPAM Copolymer Hydrogels

1．Faculty of Chemical Engineering and Light Industry，Guangdong University of Technology，Guangzhou 510006，China；
2．College of Material Science and Engineering，South China University of Technology，Guangzhou 510640，China

Online:2010-09-25 Published:2010-09-25

摘要/Abstract

摘要： 以IRGACURE2959为光引发剂，聚乙二醇双丙烯酸酯(PEGAD)和N一异丙基丙烯酰胺(NIPAM)为单体，通过紫外光引发光聚合合成了PEGDA／NIPAM共聚物水凝胶．研究了不同单体质量比凝胶材料在不同温度和pH值下的溶胀性能，测试凝胶在不同温度水中的体积相变．研究结果表明，水凝胶的平衡溶胀率随着NIPAM质量浓度增大而增大，随着环境温度的升高而减小，随着环境pH的增大而增大；NIPAM引入后，随着温度升高达到凝胶低临界溶解温度(LCST)时，凝胶平衡溶胀率及溶胀比减小明显加快，发生体积相变；随着NIPAM质量浓度的增大，凝胶溶胀饱和率减小，凝胶具备良好的延缓溶胀性能．

关键词: 聚乙二醇双丙烯酸酯；N一异丙基丙烯酰胺；水凝胶；溶胀性能；体积相变

Abstract: Copolymer hydrogels were synthesized by UV-initiated polymerization of polyethylene glycol diacrylate ester(PEGDA)and N—isopropylacrylamide(NIPAM)，with Irgacure2959 as an initiator．The swelling behavior of hydrogels with diferent mass ratio of monomer was investigated at diferent temperatures and different pH values．And the volume phase transition of hydrogels was tested in the water at diferent temperatures．The results indicate that，the equilibrium water content of the hydrogels increases with the mass contents of NIPAM monomer and the increase of pH value and decreases with the environmental temperature increasing．After NIPAM monomer is introduced into the hydrogels，with the temperature reaching the low critical solution temperature(LCST)，the decreasing of equilibrium water content and swelling ratio accelerates and volume phase transition OCCULTS．The swelling saturation ratio of the hydrogels decreases with the mass contents of NIPAM monomer increasing．Hydrogels increases the delayed swelling performance．

Key words: PEGDA；NIPAM ；hydrogels；swelling properties；volume phase transition

谭帼馨1 , 阮雄杰1 , 宁成云2 , 霍延平1 , 陈荣1 , 廖景文1. PEGDA／NIPAM 共聚物水凝胶的溶胀性能及体积相变研究[J]. 广东工业大学学报, 2010, 27(3): 5-8.

TAN Guo-Xin1 , RUAN Xiong-Jie1 , NING Cheng-Yun2 , HUO Yan-Ping1 , CHEN Rong1 , LIAO Jing-Wen1. A Study of Swelling Properties and Volume Phase Transition of PEGDA／NIPAM Copolymer Hydrogels[J]. Journal of Guangdong University of Technology, 2010, 27(3): 5-8.

参考文献

[1]顾雪蓉，朱育平．凝胶化学[M]．北京：化学工业出版社，2005．

[2]Nguyen K T，West J L．Photopolymerizable hydrogels for tissueengineering applications[J]．Biomaterials，2002，23，4307-4314．

[3]周礼，鲁智勇，张熙，等．N．异丙基丙烯酞胺共聚物的温敏性[J]．高分子材料科学与工程，2006，22(2)：165-168．

[4]Harender S Bisht，Lei Wan，Mao Guang—zhao，et a1．pH-Controlled association of PEG--Containing te~olymers of N-Iso-propylacrylamide and 1-Vinylimidazole[J]．Polymer，2005，46：7945-7952．

[5]张建，陈海燕，顾月清．PNIPA类纳米水凝胶在药物缓控释研究中的应用[J]．高分子通报，2007，(10)：52-56．

[6]Zhang Jian-tao，Huang Shi—wen，Liu Ji，et a1．Temperature sensitive poly[N—isopropylacrylamide—CO一(acryloyl beta—cyclodextrin)]for improved drug release[J]．Macromolecular Bioscience，2005，5(3)：192—196．

[7]Ramanan RM，Chellamuthu P，Tang L，et a1．Development of a Temperature--sensitive composite hydrogel for drug deliver-Y applications[J]．Biotechno1．Prog，2006，22：118-125．

[8]Cheng Nan，Liu Wen—guang，Cao Zhi—qiang，et a1．A study of thermoresponsive poly(N—isopropylac—rylamide)／polyarginine bioconjugate non—viraltransgene vectors[J]．Biomaterials，2006，27(28)：4984-4992．

[9]张传梅，付建伟，庄银凤，等．温敏性水凝胶作为固定化酶载体的研究[J]．河南科学，2006，5：683-686．

[10]冯霞，陈莉，董晶，等．快速响应温敏凝胶及其在生物分离中的应用研究[J]．南开大学学报：自然科学版，2005(6)：34 ．

[11]凌有道，吕满庚．温度和pH双重敏感性水凝胶的制备及表征[J]．精细化工，2008，29(6)：545-550．

[12]付玲，付建伟，庄银凤，等．N．异丙基丙烯酰胺的合成与表征[J]．广东化工，2007，34(7)：22-24．

[13]花兴艳，王源升，赵培仲，等．聚(丙烯酸一丙烯酰胺)的溶胀动力学[J]．石油化工，2008，38(7)：681-684．

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