广东工业大学学报 ›› 2011, Vol. 28 ›› Issue (3): 62-65.

• 综合研究 • 上一篇    下一篇

热疗用磁流体的热磁稳定性研究

  

  1. 广东工业大学 1.物理与光电工程学院,2.信息工程学院,广东 广州 510006;3. 南方医科大学 珠江医院,广东 广州 510515
  • 出版日期:2010-10-06 发布日期:2010-10-06
  • 作者简介:袁子龙(1985-),男,硕士研究生,主要研究方向为纳米功能材料.
  • 基金资助:

    国家自然科学基金资助项目(30672297);广东省自然科学基金资助项目(07300540)

Thermo-magnetic Stability of Ferrofluid for Hyperthermia

  1. 1. Faculty of Physics and Optoelectronic Engineering,  2. Faculty of Information Engineering, Guangdong University of Technology, Guangzhou 510006, China;3. Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China
  • Online:2010-10-06 Published:2010-10-06

摘要: 采用两步法制备了环糊精(β-Cyclodextrin)改性纳米四氧化三铁(Fe3O4)磁流体.通过在交变磁场下感应加热对其磁热稳定性进行了研究,在交变磁场下加热后悬浮裸磁颗粒或改性颗粒的磁性液体最高升温分别达到63 ℃和53 ℃,感应加热实验结果表明所制磁流体可用于肿瘤的热疗研究.

关键词: 磁流体;热效应;表面改性;热磁稳定性

Abstract: Water-based biocompatible fluid was prepared with magnetite particles (Fe3O4) coated with βCyclodextrin via the two-step co-precipitation method.  The thermomagnetic stabilities around induction heating in an alternating current (AC) magnetic field were investigated when the fluid was heated in the AC magnetic field for 900 s, the temperatures of magnetic fluid containing Fe3O4 nanoparticles or Fe3O4/β-Cyclodextrin composite nanoparticles rising to 63 ℃ and 53 ℃ respectively. The hyperthermic tests prove that the magnetic fluid is suitable for localized hyperthermia treatment of cancer. 

Key words: ferrofluid;heating effect;surface modification;thermo-magnetic stability

[1] Zhang Liying, Gu Hongchen, Wang Xuman. Magnetite ferrofluid with high specific absorption rate for application in hyperthermia[J].Journal of Magnetism and Magnetic Materials,2007,311:228-233.

[2] Ajay Kumar Gupta, Mona Gupta. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications[J]. Biomaterials,2005,26:3995-4021.

[3] 吴亚,孙剑飞,郭全忠,等. 肿瘤热疗用交变磁场发生器的研制[J]. 东南大学学报:自然科学版,2004,34(6): 794-796. 

[4] Jafari A, Tynjala T,Mousavi S M, et al. Simulation of heat transfer in a ferrofluid using computational fluid dynamics technique[J]. International Journal of Heat and Fluid Flow,2008,29: 1197-1202.

[5] Zhou Yanfei, Fan Tianyuan, Yang Renjie, et al. Preparation and characterization of ferromagnetic fluids for hyperthermia of tumor[J]. Journal of Chinese Pharmaceutical Sciences, 2007,16:187-191.

[6] Qu Jingmiao, Liu Guang, Wang Yiming, et al. Preparation of Fe3O4chitosan nanoparticles used for hyperthermia[J],Advanced Powder Technology,2010,21:461-467.

[7] Goodarzi A, Sahoo Y, Swihart M T, et al. Aqueous ferrofluid of citric acid coated magnetite particles[J]. Materials Research Society SymposiumProceedings, Quantum Dots, Nanoparticles and Nanowires, 2003,789: 129-134S. 

[8] Alberto BocanegraDiaza N D S, Mohallema M A, Novakb, et al. Preparation of ferrofluid from cyclodextrin and magnetite[J]. Journal of Magnetism and Magnetic Materials,2004,272-276:2395-2397.

[9] 张伟,沈辉, 夏建汉,等. 聚乙烯亚胺改性水基磁性液体的吸附特性[J]. 纳米技术与精密工程,2006,5(2): 125128.〖ZK)〗

[10] Yu Changlin, Wen Herui, YU Jimmy C. Preparation of different magnetic Fe3O4 nanocrystals under mild conditions with different poly (ethylene glycol)[J]. Nanotechnology and Precision Engineering, 2010,8(2): 161-166.

[11] Podzus P E,Daraio ME,Jacobo S E. Chitosan magnetic microspheres for technological applications: Preparation and characterization[J]. Physica B,2009,404:2710-2712.

[12] Zhang Wei, Shen Hui, Xie Minqiang, et al. Synthesis of carboxymethylchitosanbound magnetic nanoparticles by the spraying coprecipitation method[J]. Scripta Materialia,2008,59:211-214.

[13] Mrudul Gadhvi. Magnetic behavior of magnetically tunable Fe3O4 polymer composites[J]. Materials Science and Engineering B,2010,168:106-110.

[14] Adriana P Herrera, Carola Barrera, Yashira Zayas,et al.Monitoring colloidal stability of polymercoated magnetic nanoparticles using AC susceptibility measurements[J]. Journal of Colloid and Interface Science,2010, 342 : 540-549.

[15] 王煦漫,古宏晨,杨正强,等. 磁热疗用Fe3O4在交变磁场中的热效应[J].上海交通大学学报,2005,39(2):275-278.
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