Abstract: Considering the impact of novel coronavirus pneumonia (COVID-19), the main factors influencing travel mode choice behavior of residents were analyzed from the aspects of traveler attributes and travel characteristics for the three periods of COVID-19 epidemic: early-stage, mid-stage, and late-stage. The Nested Logit model was adopted to establish the travel mode choice model because of a correlation between travel modes. Influence factors of travel mode choice behavior in different stages of COVID-19 epidemic were analyzed using the SP data of residents in Tanzhou Town, Zhongshan City. The results showed that the significant factors influencing travel mode choice behavior were different in different epidemic periods, and the influence degree of the same factor was also different in different epidemic periods. These results can provide support for relevant authorities to formulate abnormal traffic management measures under public health emergencies.