面向fMRI时序数据的多层级特征交互融合脑疾病诊断模型

    A Multilevel Feature Interaction Fusion Model for Brain Disease Diagnosis Based on fMRI Time Series Data

    • 摘要: 功能性磁共振成像(Functional Magnetic Resonance Imaging, fMRI)以其高维数据的特性在脑疾病识别研究中展现了相当的潜力,但现有深度学习方法对多尺度的时间特征缺乏敏感度,尤其是缺少对短时间血氧水平依赖(Blood-oxygen Level Depend, BOLD)信号变化的有效利用。为此,本文提出了一种多层级BOLD信号特征交互融合模型。模型基于脑图谱将BOLD信号划分为感兴趣区域构建时间序列,编码后分别使用滑动窗口与多头自注意力捕获全局特征,分布特异度注意力机制提取局部特征,随后将从全局和局部提取的多尺度信息融合,输入线性层进行疾病识别。此外,利用基于聚类的可解释性分析揭示了在脑疾病识别过程中最具相关性的脑区。在ADNI数据集上的实验结果表明所提出的方法相较于最优对比方法提升了3.9个百分点的准确度,在ABIDE I数据集上提升了2.5个百分点的准确度。同时,模型定位到的异常脑区功能与阿尔茨海默症和自闭症谱系障碍的临床表现具有高度一致性。

       

      Abstract: Functional Magnetic Resonance Imaging (fMRI) has shown considerable potential in brain disease identification due to its high-dimensional data characteristics. However, existing deep learning methods lack sensitivity to multi-scale temporal features. To address this, we propose a multi-level Blood Oxygenation Level Dependent signal feature interaction fusion model. The model divides BOLD signals into regions of interest based on a brain atlas to construct time series. After encoding, sliding window and multi-head self-attention mechanisms are used to capture global features and a distribution-specific attention mechanism is employed to extract local features. The multi-scale information extracted from both global and local features is then fused and input into a linear layer for disease recognition. Additionally, an explainability analysis based on clustering reveals the most relevant brain regions in the process of brain disease identification. Experiment results show that the proposed method improves accuracy by approximately 3.9% and 2.5% compared to the optimal baseline methodon the on the ADNI and ABIDE I datasets, respectively. Furthermore, the abnormal brain regions identified by the proposed model are highly consistent with the clinical manifestations of Alzheimer's disease and Autism Spectrum Disorder.

       

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