广东工业大学学报 ›› 2011, Vol. 28 ›› Issue (2): 91-94.

• 综合研究 • 上一篇    

采用DSC技术观察正极性驻极体对大鼠皮肤结构的影响

  

  1. 1.第二军医大学 基础部数理教研室，上海 200433； 2.第二军医大学 药学院无机教研室，上海 200433
  • 出版日期:2011-06-25 发布日期:2011-06-25
  • 作者简介:董法杰（1979-），男，讲师，主要研究方向为驻极体透皮机制.
  • 基金资助:

    国家自然科学基金资助（50977089）；军队“十一五”国际合作项目(06H022)；上海市自然科学基金资助（10ZR1437600）〖JP〗

DSC Analysis of the Effect of Positive Electret on Rat Skin

  1. 1.School of Pharmacy, Second Military Medical University, Shanghai 200433，China；
    2.College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433，China
  • Online:2011-06-25 Published:2011-06-25

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摘要： 利用恒压电晕充电技术将聚丙烯制备成不同表面电位的正极性驻极体，将驻极体作用于SD大鼠2 h，借助热分析技术对大鼠皮肤的差示扫描量热（DSC）图谱进行研究.结果显示：1）正常大鼠皮肤的DSC图谱中位于63 ℃、82.7 ℃和115.1 ℃出现了3个特征相变峰.2）与对照组的DSC图谱相比，大鼠皮肤DSC图谱中相变峰的峰值和峰面积随驻极体表面电位的增加而减少.结果：正极性驻极体的生物效应改变了大鼠皮肤角质层中层状类脂和蛋白质的空间结构，增强了类脂的流动性.正极性驻极体具有促进药物经皮渗透的作用.

关键词: 驻极体；聚丙烯；DSC图谱；大鼠；皮肤

Abstract: The positive electret was prepared by the constant voltage corona charging method. After the application of the electret on rat skin for 2 hours, the skin was analyzed by differential scanning calorimetry (DSC). The results indicate that (1) there are three peaks at 65 ℃, 87 ℃ and 122 ℃ in the DSC spectra for control rat skin; (2) with the increase of electret surface potential, the peak temperature and peak area decrease as compared with control rat skin. Therefore, the biological effect of positive electret changes the space structure of lamellar lipid and protein, and increases the fluidity of lipid. Positive electret can enhance the drug transdermal delivery.

Key words: electret; polypropylene; differential scanning calorimetry spectra; rat; skin

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