Journal of Guangdong University of Technology ›› 2020, Vol. 37 ›› Issue (04): 91-97.doi: 10.12052/gdutxb.190090

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Molecular Probes Targeting TSPO for Neuroinflammatory Imaging

Zang Xiao-hao, Liu Qi-fa, Hu Meng-meng, Chang Yuan-yuan, Xiao Qing-wei, Zhou Wei   

  1. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China
  • Received:2019-07-05 Online:2020-07-11 Published:2020-07-02

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Abstract: Neuroinflammation runs through the whole course of neurodegenerative diseases. In normal physiological state, nerve inflammation contributes to the repair of nervous system damage, while excessive inflammation can cause cellular damage, accelerating the deterioration of neurodegenerative diseases. When nerve inflammation occurs, microglia cells are activated, which makes them a sensitive and specific quantitative indicator to reflect the pathophysiological changes of microglia cells. Nuclide and visible light imaging technologies were used to detect neuroinflammatory targets, and the research progress of molecular probes targeting TSPO targets in recent years was introduced, including nuclide imaging and fluorescence imaging. Finally, the application prospect and market value of the neuroinflammatory molecular probes are summarized and forecasted, which is of certain reference significance for the development of novel neuroinflammatory molecular probes.

Key words: neuroinflammation, translocator protein (TSPO), molecular probes

CLC Number: 

  • R749.16
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