Journal of Guangdong University of Technology ›› 2010, Vol. 27 ›› Issue (2): 40-42.

• Comprehensive Studies • Previous Articles     Next Articles

Antibacterial Activity of Novel Quinoline Derivatives Containing Piperazine

  

  1. School of Chemistry and Chemical Engineering,Zhaoqing Institute,Zhaoqing 526060,China
  • Online:2010-06-25 Published:2010-06-25

Abstract: To develop novel antibacterial medicinals with high activity,antibacterial tests of 1 3 novel quinoline derivatives containing piperazine were conducted.The experimental results show that the compounds 3i and 3j possess good antibacterial activity against Escherichia coli,Bacillus subtilis and Staphylococcus aureus,and their MICs ale 0.07 mg/mL.

Key words: quinoline;piperazine;antibacterial activity

[1]Aik H R P,Naik H S B,Naik T R R,et a1.Synthesis of novel benzo[h]quinolines:Wound healing,antibacterial,DNA binding and in vitro antioxidant activity[J].Eur J Med Chem,2009,44(3):981-989.

[2]Via L D,Gia O,Gasparotto V,et a1.Discovery of a new anilino-3H-pyrrolo[3,2-f]quinoline derivative aspotential anti-cancer agent[J].Eur J Med Chem,2008,43(2):429-434.

[3]Prescott T A K,Sadler I H,Kiapranis R.Lunacridine from Lunasia amara is a DNA intercalating topoisomerase II inhibitor[J].Journal of Ethnopharmaeology,2007,109(2),289-294.

[4]郑贤育,陈昌,高芳华,抗疟新药咯萘啶及其类似物的合成[J].药学学报,1982,2:118.

[5]单成启,高徐生.磷酸萘酚喹对人恶性疟原虫体外药效测定[J].军事医学科学院院刊,1995,19(4):317.

[6]Kwiek J J,Haystead T A J,Rudolph J.Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines[J].Biochemistry,2004,43(15):4538-4547.

[7]周宝石,曾志正.辛可芬与8一羟基喹啉稀土三元配合物的合成及有关烧伤的药学性质研究[J].兰州大学学报:自然科学版,2005,41(3):60-62.

[8]王小京.美科学家告诫慎防淋病死灰复燃[J].国外医学情报,2003,24(7):32-33.

[9]赖以飞.综合最近开发杀菌剂的作用方式[J].农药译丛,1997,19(1):14-19.

[10]吴利欢,杨定乔.2-(取代哌嗪-1-甲基).3-喹啉甲酸.乙酯及其衍生物的合成、表征及晶体结构[J].有机化学,2009,29(7):1122-1128.
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