Journal of Guangdong University of Technology ›› 2010, Vol. 27 ›› Issue (3): 5-8.

• Comprehensive Studies • Previous Articles     Next Articles

A Study of Swelling Properties and Volume Phase Transition of PEGDA／NIPAM Copolymer Hydrogels

  

  1. 1．Faculty of Chemical Engineering and Light Industry，Guangdong University of Technology，Guangzhou 510006，China；
    2．College of Material Science and Engineering，South China University of Technology，Guangzhou 510640，China
  • Online:2010-09-25 Published:2010-09-25

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Abstract: Copolymer hydrogels were synthesized by UV-initiated polymerization of polyethylene glycol diacrylate ester(PEGDA)and N—isopropylacrylamide(NIPAM)，with Irgacure2959 as an initiator．The swelling behavior of hydrogels with diferent mass ratio of monomer was investigated at diferent temperatures and different pH values．And the volume phase transition of hydrogels was tested in the water at diferent temperatures．The results indicate that，the equilibrium water content of the hydrogels increases with the mass contents of NIPAM monomer and the increase of pH value and decreases with the environmental temperature increasing．After NIPAM monomer is introduced into the hydrogels，with the temperature reaching the low critical solution temperature(LCST)，the decreasing of equilibrium water content and swelling ratio accelerates and volume phase transition OCCULTS．The swelling saturation ratio of the hydrogels decreases with the mass contents of NIPAM monomer increasing．Hydrogels increases the delayed swelling performance．

Key words: PEGDA；NIPAM ；hydrogels；swelling properties；volume phase transition

[1]顾雪蓉，朱育平．凝胶化学[M]．北京：化学工业出版社，2005．

[2]Nguyen K T，West J L．Photopolymerizable hydrogels for tissueengineering applications[J]．Biomaterials，2002，23，4307-4314．

[3]周礼，鲁智勇，张熙，等．N．异丙基丙烯酞胺共聚物的温敏性[J]．高分子材料科学与工程，2006，22(2)：165-168．

[4]Harender S Bisht，Lei Wan，Mao Guang—zhao，et a1．pH-Controlled association of PEG--Containing te~olymers of N-Iso-propylacrylamide and 1-Vinylimidazole[J]．Polymer，2005，46：7945-7952．

[5]张建，陈海燕，顾月清．PNIPA类纳米水凝胶在药物缓控释研究中的应用[J]．高分子通报，2007，(10)：52-56．

[6]Zhang Jian-tao，Huang Shi—wen，Liu Ji，et a1．Temperature sensitive poly[N—isopropylacrylamide—CO一(acryloyl beta—cyclodextrin)]for improved drug release[J]．Macromolecular Bioscience，2005，5(3)：192—196．

[7]Ramanan RM，Chellamuthu P，Tang L，et a1．Development of a Temperature--sensitive composite hydrogel for drug deliver-Y applications[J]．Biotechno1．Prog，2006，22：118-125．

[8]Cheng Nan，Liu Wen—guang，Cao Zhi—qiang，et a1．A study of thermoresponsive poly(N—isopropylac—rylamide)／polyarginine bioconjugate non—viraltransgene vectors[J]．Biomaterials，2006，27(28)：4984-4992．

[9]张传梅，付建伟，庄银凤，等．温敏性水凝胶作为固定化酶载体的研究[J]．河南科学，2006，5：683-686．

[10]冯霞，陈莉，董晶，等．快速响应温敏凝胶及其在生物分离中的应用研究[J]．南开大学学报：自然科学版，2005(6)：34 ．

[11]凌有道，吕满庚．温度和pH双重敏感性水凝胶的制备及表征[J]．精细化工，2008，29(6)：545-550．

[12]付玲，付建伟，庄银凤，等．N．异丙基丙烯酰胺的合成与表征[J]．广东化工，2007，34(7)：22-24．

[13]花兴艳，王源升，赵培仲，等．聚(丙烯酸一丙烯酰胺)的溶胀动力学[J]．石油化工，2008，38(7)：681-684．
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